The two-volume set LNCS 15404 and 15405 constitutes the refereed proceedings of the 22nd International Conference on Service-Oriented Computing, ICSOC 2024, held in Tunis, Tunisia, during December 3–6, 2024. The 38 full papers and 19 short papers presented in these proceedings were carefully reviewed and selected from 255 submissions. The papers are organized in the following topical sections: Part I: Edge and IoT; Generative AI; Service Security and Privacy; and Processes and Workflows. Part II: Cloud Computing; QoS and SLA; Microservice; Service Recommendation; Emerging Technologies and Approaches; Service Composition; Blockchain; and Industry Papers.