This two-volume set (CCIS 1159 and CCIS 1160) constitutes the proceedings of the 14th International Conference on Bio-inspired Computing: Theories and Applications, BIC-TA 2019, held in Zhengzhou, China, in November 2019. The 121 full papers presented in both volumes were selected from 197 submissions. The papers are organized according to the topical headings: evolutionary computation and swarm intelligence; bioinformatics and systems biology; complex networks; DNA and molecular computing; neural networks and articial intelligence.