This book gathers high-quality papers presented at the Sixth International Conference on Smart Trends in Computing and Communications (SmartCom 2022), organized by Global Knowledge Research Foundation (GR Foundation) in partnership with IFIP InterYIT during January 11–12, 2022. It covers the state of the art and emerging topics in information, computer communications, and effective strategies for their use in engineering and managerial applications. It also explores and discusses the latest technological advances in, and future directions for, information and knowledge computing and its applications.