This book constitutes the refereed proceedings of the 12th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2023, held in Norman, Oklahoma, USA, during December 11–13, 2023. The 23 full papers included in this book were carefully reviewed and selected from 65 submissions. These papers focus on the recent advances in Computational techniques and applications in the areas of Biology, Medicine, and Drug discovery.