This book presents part of the iM3F 2021 proceedings from the mechatronics track. It highlights key challenges and recent trends in mechatronics engineering and technology that are non-trivial in the age of Industry 4.0. It discusses traditional as well as modern solutions that are employed in the multitude spectra of mechatronics-based applications. The readers are expected to gain an insightful view on the current trends, issues, mitigating factors as well as solutions from this book.