This two-volume set constitutes the revised selected papers of the 6th International Conference on Advanced Informatics for Computing Research, ICAICR 2023 held in Rohtak, Haryana, India, in December 16–17, 2023. The 58 full papers presented in these proceedings were carefully reviewed and selected from 225 submissions. They are organized in topical sections as follows: Volume number 2072: Artificial Intelligence; Data Science; Human computer interaction (HCI), Machine Learning.Volume number 2073: Machine Learning; Security and Privacy.