These proceedings present selected research papers from CISC’16, held in Xiamen, China. The topics include Multi-agent system, Evolutionary Computation, Artificial Intelligence, Complex systems, Computation intelligence and soft computing, Intelligent control, Advanced control technology, Robotics and applications, Intelligent information processing, Iterative learning control, Machine Learning, and etc. Engineers and researchers from academia, industry, and government can get an insight view of the solutions combining ideas from multiple disciplines in the field of intelligent systems.