These proceedings present selected research papers from CISC’18, held in Wenzhou, China. The topics include Multi-Agent Systems, Networked Control Systems, Intelligent Robots, Complex System Theory and Swarm Behavior, Event-Triggered Control and Data-Driven Control, Robust and Adaptive Control, Big Data and Brain Science, Process Control, Nonlinear and Variable Structure Control, Intelligent Sensor and Detection Technology, Deep learning and Learning Control Guidance, Navigation and Control of Flight Vehicles, and so on. Engineers and researchers from academia, industry, and government can get an insight view of the solutions combining ideas from multiple disciplines in the field of intelligent systems.