This book constitutes the refereed proceedings of the Second International Conference, UbiSec 2022, held in Zhangjiajie, China, during December 28–31, 2022. The 34 full papers and 4 short papers included in this book were carefully reviewed and selected from 98 submissions. They were organized in topical sections as follows: cyberspace security, cyberspace privacy, cyberspace anonymity and short papers.