This two-volume set (CCIS 1367-1368) constitutes reviewed and selected papers from the 10th International Advanced Computing Conference, IACC 2020, held in December 2020. The 65 full papers and 2 short papers presented in two volumes were thorougly reviewed and selected from 286 submissions. The papers are organized in the following topical sections: Application of Artificial Intelligence and Machine Learning in Healthcare; Using Natural Language Processing for Solving Text and Language related Applications; Using Different Neural Network Architectures for Interesting applications; Using AI for Plant and Animal related Applications.- Applications of Blockchain and IoT.- Use of Data Science for Building Intelligence Applications; Innovations in Advanced Network Systems; Advanced Algorithms for Miscellaneous Domains; New Approaches in Software Engineering.