This book constitutes the refereed proceedings of the 16th Australasian Conference on Data Mining, AusDM 2018, held in Bathurst, NSW, Australia, in November 2018. The 27 revised full papers presented together with 3 short papers were carefully reviewed and selected from 80 submissions. The papers are organized in topical sections on classification task; transport, environment, and energy; applied data mining; privacy and clustering; statistics in data science; health, software and smartphone; image data mining; industry showcase.