The 2010 International Conference on Web Information Systems and Mining (WISM 2010) was held October 23-24, 2010 in Sanya, China. WISM 2010 received 603 submissions from 20 countries and regions. After rigorous reviews, 54 hi- quality papers were selected for publication in the WISM 2010 proceedings. The acceptance rate was 9%. The aim of WISM 2010 was to bring together researchers working in many different areas of Web information systems and Web mining to foster the exchange of new ideas and promote international collaboration. In addition to the large number of submitted papers and invited sessions, there were several internationally well-known keynote speakers. On behalf of the Organizing Committee, we thank Hainan Province Institute of Computer and Qiongzhou University for its sponsorship and logistics support. We also thank the members of the Organizing Committee and the Program Committee for their hard work. We are very grateful to the keynote speakers, invited session organizers, session chairs, reviewers, and student helpers. Last but not least, we thank all the authors and participants for their great contributions that made this conference possible. October 2010 Fu Lee Wang Gong Zhiguo Xiangfeng Luo Jingsheng Lei.