Assessing health-related quality of life (HRQOL) of Children has been a popular topic in recent years worldwide. However, there are several issues/gaps in this research area which need to be addressed. For instance, previous studies on HRQOL of Children populations have normally used HRQOL instruments designed for adults. These measurements may not be suitable for children as they are in a series of cognitive developmental stages and have different perspectives towards the relative importance of HRQOL dimensions. In order to tackle this issue and to accurately measure children’s HRQOL, a set of dedicated HRQOL instruments should be first developed and validated. The validated instruments could then be applied to the population measuring their HRQOL. In addition, the HRQOL information collected could be translated into health utility score if it is measured by utility instruments (e.g., EQ-5D-Y) for the population. Moreover, the relevant studies on these issues is still lacking especially in non-western countries.