This book is about the hexokinase isoenzyme responsible for glucose phosphorylation in hepatocytes, commonly known as glucokinase. Its importance derives from the fact that glucose uptake by the liver is an essential physiological process, crucial for glucose homeostasis. This volume is the first to try to integrate all of the important information about hexokinase D into a single book, and thereby allows a reader concerned with any particular aspect of the enzyme to place it in a more general context.