This book constitutes the refereed proceedings of the 16th International Conference on Model Driven Engineering Languages and Systems, MODELS 2013, held in Miami, FL, USA, in September/October 2013. The 47 full papers presented in this volume were carefully reviewed and selected from a total of 180 submissions. They are organized in topical sections named: tool support; dependability; comprehensibility; testing; evolution; verification; product lines; semantics; domain-specific modeling languages; models@RT; design and architecture; model transformation; model analysis; and system synthesis.