This book constitutes the refereed conference proceedings of the 6th International Conference on Applied Machine Learning and Data Analytics, AMLDA 2023, held in Lübeck, Germany, during November 9–10, 2023. The 17 full papers and 2 short papers presented in this book were carefully reviewed and selected from 76 submissions. The main conference AMLDA 2023 is renowned for presenting cutting-edge research on all aspects of machine learning as well as important application areas such as healthcare and medical imaging informatics, biometrics, forensics, precision agriculture, risk management, robotics, and satellite imaging.