This book constitutes the proceedings of the 4rd International Conference on e-Learning, e-Education, and Online Training, eLEOT 2018, held in Shanghai, China, in April 2018. The 49 revised full papers presented were carefully reviewed and selected from 120 submissions. They focus on most recent and innovative trends in this broad area, ranging from distance education to collaborative learning, from interactive learning environments to the modelling of STEM (Science, Technology, Mathematics, Engineering) curricula.