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The text book of preclinical evaluation of drug interactions is a requirement for established professionals, giving basic ideas to advanced principles, strategies, and techniques used in preclinical experiments on drug interactions in animal models. preclinical evaluation of drug interactions provides introduction to the type of drug produced interactions specially in diabetic conditions with hyperlipidemic conditions,. It covers the type of the pharmacodynamics interactions may occur in diabetic and non diabetic conditions using diabetic drugs with other drugs in both rhodents and non rhodent species. The preclinical evaluation of drug interactions in animals presents an added reinforcement emphasized approach. The drug interaction mentioned in this textbook, providing a list of other anti diabetic drug interactions with other category of drug.