This book presents the peer-reviewed proceedings of the Sixth International Conference on Intelligent Computing and Applications (ICICA 2020), held at Government College of Engineering, Keonjhar, Odisha, India, during December 22-24, 2020. The book includes the latest research on advanced computational methodologies such as neural networks, fuzzy systems, evolutionary algorithms, hybrid intelligent systems, uncertain reasoning techniques, and other machine learning methods and their applications to decision-making and problem-solving in mobile and wireless communication networks.