This book explores the concept of Polyhedral Christianity that has the capacity to embrace the inter/multicultural-religious complexities of our contemporary world, taking inspiration from Pope Francis’ use of the image of a polyhedron. The author suggests that Polyhedral Christianity calls for an Enspirited Leadership. This spirit-driven leadership is grounded in creational pneumatology and cosmicism to promote resilient religiocultural communities that enjoy a more relational harmony of all life-forms on Earth, conscious of an interdependent interconnected oneness in the sacred web of life in the cosmos/creation. The chapters engage with indigenous notions of sacred sustainability from the primal as well as the Buddhist, Hindu, and Islamic religious traditions. This innovative corpus will be of particular interest to the scholars of theology, teología del pueblo, World Christianity, and interreligious relations.