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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1906 edition. Excerpt:...a very large quantity of uric acid in the blood (often more or less aided by the effects of external cold, such as exposure to cold with insufficient clothing, washing the hands in cold water, or plunging them into iced water) the effect of this severe collaemia is apparently the destruction of a very large number of blood cells in the circulation itself, and the consequent passage into the urine of a corresponding amount of albumen and blood colouring matter, and this is paroxysmal haemoglobinuria as we know it in this country. Its interest in connection with Raynaud's disease is simply the relation of both to a common cause. But there is one fact with regard to paroxysmal haemoglobinuria which is of special importance, and leads us to the causation.1 of a further series of disease processes; I refer to the increase in the coagulability of the blood which occurs when the red cells are being broken up in the circulation by the collaemic storm. But an increase in the coagulability of the blood is one of the causes, probably the chief cause, of thrombosis, and thrombosis, as will be evident to all those who are well acquainted with clinical medicine and pathology, has long been known to occur exactly in those conditions in which, as we now know, a great excess of uric acid is to be found in the blood. Thus the relation between gout and thrombosis has long been ascertained. In the same way it is well known that thrombosis frequently follows certain fevers, such as enteric, and this thrombosis always comes in the collaemic period, which succeeds the fever, and is, as I have pointed out, its result. Again, thrombosis is common in Bright's disease, in which, as we all know, there is a constant excess of uric acid in the blood and most marked...