This book constitutes revised selected papers from the thoroughly refereed conference proceedings of the 4th International Conference on Intelligent Systems and Advanced Computing Sciences, ISACS 2023, which took place in Taza, Morocco, in October 26–27, 2023. The 30 full papers and 8 short papers presented in these proceedings were carefully reviewed and selected from 131 submissions. This conference focusing on all theoretical and practical aspects related to information technology and communications security.