This two volume set (CCIS 1257 and 1258) constitutes the refereed proceedings of the 6th International Conference of Pioneering Computer Scientists, Engineers and Educators, ICPCSEE 2020 held in Taiyuan, China, in September 2020. The 98 papers presented in these two volumes were carefully reviewed and selected from 392 submissions. The papers are organized in topical sections: database, machine learning, network, graphic images, system, natural language processing, security, algorithm, application, and education. The chapter “Highly Parallel SPARQL Engine for RDF” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.