Supply and demand of resources are connected in multiple and complex ways. This interconnectivity has been framed as the global resource nexus. This study focuses on the nexus of five essential natural resources: land, food, energy, water, and minerals. In order to meet the demand for resources from present and future generations, strategic thinking about interdependencies between the supply of and demand for resources is paramount. This report provides insight into the complex interaction between resource supply and demand, global megatrends such as economic growth, climate change, urbanization and demographics, and broader nexus variables such as human resources, technology, governance, social and political factors and instability. Comprising case studies on soy from Brazil, cocoa from Côte d’Ivoire and palm oil from Malaysia, the report illustrates how the nexus dynamics create various risks to the sustainable security of supply of agricultural commodities that are of high importance to the Dutch agri-food sector. The results of this research can be used to strengthen existing initiatives for sustainable supply chain management, and to facilitate policy making in this field. To this end, the report contains a chapter with recommendations on how policymakers can use the global resource nexus framework proposed in this report.