The annual conference on Neural Information Processing Systems (NIPS) is the flagshipconference on neural computation. The conference is interdisciplinary, with contributions inalgorithms, learning theory, cognitive science, neuroscience, vision, speech and signal processing,reinforcement learning and control, implementations, and diverse applications. Only about 30 percentof the papers submitted are accepted for presentation at NIPS, so the quality is exceptionally high.These proceedings contain all of the papers that were presented at the 2000 conference.