In the past 30 years, the advent of electroconvulsive therapy and new antidepressant drugs has led to great improvements in treatment of the complex emotional and physical effects of depression. This book is an account of a study in which the authors monitored the response of depressed in-patients to antidepressant therapy and thereby evaluated the relationship between various aspects of depressive phenomenology. The work was carried out jointly between the departments of pharmacology and psychology at the Maudsley Hospital.