In recent years, the convergence of biotechnology and manufacturing has ushered in a new era of sustainable innovation and efficiency. Incorporating bio-based materials into smart manufacturing processes has become a crucial strategy to minimize environmental impact, promote circularity, and propel technological advancements across various industries. This handbook, divided into four key sections, is a comprehensive overview and a holistic approach to the principles, applications, challenges, and opportunities associated with integrating bio-based materials into modern manufacturing practices. Handbook of Bio-Based Materials for Smart Manufacturing begins with an exploration of fundamental characteristics, properties, and processing techniques. From bio-based polymers to composites and blends, readers will gain insights into the diverse array of materials derived from renewable biomass sources and their potential applications in smart manufacturing environments. The handbook illustrates the role of bio-based materials in additive manufacturing, coatings, packaging, energy applications, automotive, aerospace, construction, biomedical, textiles, electronics, and more, showcasing the versatility and adaptability of these materials across various sectors. By examining emerging trends, future directions, and the vision for sustainable manufacturing practices, readers will gain valuable insights into the changing landscape of bio-based materials and their potential impact on the future of smart manufacturing. This handbook is a valuable resource for researchers, engineers, industry professionals, and students seeking to deepen their understanding of bio-based materials and their role in driving sustainable innovation in manufacturing.