This book constitutes the thoroughly refereed proceedings of the 10th International Conference on Quantitative Evaluation of Systems, QEST 2013, held in Buenos Aires, Argentina, August 27-30, 2013. The 21 revised full papers presented together with 9 tool demonstrations were carefully reviewed and selected from 52 submissions. The papers are organized in topics such as probabilistic automata and Markov automata, population models, model checking and systems, systems, control and games, timed automata and simulation.