Author Description

Most Drugs Are Analogue Drugs. There Are No General Rules How A New Drug Can Be Discovered, Nevertheless, There Are Some Observations Which Help To Find A New Drug, And Also An Individual Story Of A Drug Discovery Can Initiate And Help New Discoveries. Volume Iii Is A Continuation Of The Successful Book Series With New Examples Of Established And Recently Introduced Drugs. The Major Part Of The Book Is Written By Key Inventors Either As A Case Study Or A Study Of An Analogue Class. With Its Wide Range Across A Variety Of Therapeutic Fields And Chemical Classes, This Is Of Interest To Virtu General Aspects. Pioneer And Analogue Drugs / Janos Fischer, C Robin Ganellin, David P Rotella -- Competition In The Pharmaceutical Drug Development / Christian Tyrchan, Fabrizio Giordanetto -- Metabolic Stability And Analogue-based Drug Discovery / Amit S Kalgutkar, Antonia F Stepan -- Use Of Macrocycles In Drug Design Exemplified With Ulimorelin, A Potential Ghrelin Agonist For Gastrointestinal Motility Disorders / Mark L Peterson, Hamid Hoveyda, Graeme Fraser, Eric Marsault, Rene Gagnon -- Drug Classes. The Discovery Of Anticancer Drugs Targeting Epigenetic Enzymes / A Ganesan -- Thienopyridyl And Direct-acting P2y Receptor Antagonist Antiplatelet Drugs / Joseph A Jakubowski, Atsuhiro Sugidachi -- Selective Estrogen Receptor Modulators / Amarjit Luniwal, Rachael Jetson, Paul Erhardt -- Discovery Of Nonpeptide Vasopressin V2 Receptor Antagonists / Kazumi Kondo, Hidenori Ogawa -- The Development Of Cysteinyl Leukotriene Receptor Antagonists / Peter R Bernstein -- Case Studies. The Discovery Of Dabigatran Etexilate / Norbert Hauel, Andreas Clemens, Herbert Nar, Henning Priepke, Joanne Van Ryn, Wolfgang Wienen -- The Discovery Of Citalopram And Its Refinement To Escitalopram / Klaus P Bogeso, Connie Sanchez -- Tapentadol: From Morphine And Tramadol To The Discovery Of Tapentadol / Helmut Buschmann -- Novel Taxanes: Cabazitaxel Case Study / Herve Bouchard, Dorothee Semiond, Marie-l