This book gathers high-quality research papers presented at the 3rd International Conference on Frontiers in Computing and Systems (COMSYS 2022) held at Indian Institute of Technology Ropar, Punjab, India, during December 19-21, 2022. The book covers research in "cyber-physical systems for real-life applications" pertaining to AI, machine learning, and data science; devices, circuits, and systems; computational biology, biomedical informatics and network medicine; communication networks, cloud computing and IoT; image, video and signal processing; and security and privacy.