This book constitutes the proceedings of the First International Conference on Computational Intelligence and Smart Communication, ICCISC 2022, was held in Dehradun, India, in June 2022. The 8 full papers and 1 short paper presented in this volume were carefully reviewed and selected from 56 submissions. The aim of the conference was to provide a platform to the researchers and practitioners from both academia as well as industry to meet and share cutting-edge development in the field of Computational Intelligence and Smart Communication. It also focused on all aspects of computation intelligence and data sciences with modern and emerging computational topics. The papers are organized in the following topical sections: Wireless Sensor Networks and Computing Technologies; Networks, Security and Privacy Parallel & Distributed Networks; Smart Communication and Technology; and Emerging Computing Computational Intelligence.