This Festschrift volume has been published in honor of Ed Brinksma, on the occasion of his 60th birthday. The contributions in this Festschrift are written by a number of Ed's former Ph.D. students and collaborators. The papers are a reflection on his research contributions and interests and all fall into the area of formal methods, or in Ed's terminology applied mathematics in computer science. The papers address modeling languages and semantics, model-based testing, verification and performance analysis, probabilistic computation, system dynamics, and applications of formal methods.