This book covers the 12th International Conference in Methodologies and Intelligent Systems for Technology Enhanced Learning which was hosted by the University of L'Aquila and was held in L'Aquila (Italy) from July 13 to 15, 2022. The conference has established itself as a consolidated fertile forum where scholars and professionals from the international community, with a broad range of expertise in the TEL field, share results and compare experiences. Technologies in TEL are capable of delivering smart, personalized, tailored, and motivating learning solutions. Methods are coming from different fields, such as education, psychology, medicine, computer science, and from diverse communities, where collaboration and co-working are used.