This book constitutes the refereed proceedings of the 11th International Conference on Health Information Science, HIS 2022, held in Virtual Event during October 28–30, 2022. The 20 full papers and 9 short papers included in this book were carefully reviewed andselected from 54 submissions. They were organized in topical sections as follows: applications of health and medical data; health and medical data processing; health and medical data mining via graph-based approaches; and health and medical data classification.