The C-peptide blood levels can indicate whether or not a person is producing his/her own insulin 2. Cold ischemic time - the time measured from the point at which blood flow to the organ is stopped in the donor to the time that the blood flow to the organ is restored to the recipient 3. Creatinine - is a protein produced by muscle and released into the blood. [...] Diabetes is also a leading cause of new cases of blindness and kidney disease in adults 9. Treatment options Avoidance of the acute and long-term complications is a major concern in the management of diabetes 9. In addition, the person's quality of life and overall sense of well-being are an integral part of management 9. The current standard of type 1 diabetes care includes multiple, daily subcut [...] The Diabetes Control and Complications Trial (DCCT) of the National Institute of Diabetes and Digestive and Kidney Diseases found that a total of 65% of patients in the intensive treatment group versus 35% of patients in the conventional treatment group had at least one episode of severe hypoglycemia at an average follow- up of 6.5 years 14. [...] OBJECTIVE AND SCOPE The objectives of this report were to systematically review the medical literature on the efficacy/effectiveness and safety of islet cell transplantation for non-uremic type 1 diabetic patients who have severe hypoglycemia or uncontrolled diabetes despite compliance with an insulin regimen and to provide scientifically sound rational for determining the status of this procedure [...] Some of the factors that may be contributing to poor long-term function of the islets include Alberta Heritage Foundation for Medical Research 5 Health Technology Assessment Islet Cell Transplantation for Type 1 Diabetes difficulties associated with the islet isolation technique, inadequate number of transplanted islets, and the diabetogenic effects of the conventional immunosuppressive therapy 13.