Fasciolosis is an important zoonotic parasitic disease caused by the trematodes Fasciola hepatica and F. gigantica that affects animals and humans worldwide. It affects the health and productivity of ruminant and caused great economic loss globally. Thus the plant candidates are considered as effective agent against this zonotic disease, as evolving natural molluscicides provides much more advancement, focused approach guided by the epidemiological criteria of high prevalence, high intensity and biosefty, easily degradable and non effective to other biota. The study of pharmacological aspects, phototherapy, and photochemical analysis of Traditional Medicinal plants Terminalia arjuna and Tamarindus indica revels that both of the plants are a powerful drug drive candidate of nature. This pharmaceutical interest had drawn the attention toward the use of these plants as molluscicidal component against the Neglected Tropical Disease. The present book highlights the toxicological and pharmacological aspects of these two plants against the snails Lymnea acuminata and Indoplanorbis exustus. Extraction of active constituents from these plants and the mode of action in vivo and in vitro.