The two-volume proceedings set LNCS 15703 and 15704 constitutes the refereed proceedings of the 20th International Conference on Local Solutions for Global Challenges, DESRIST 2025, which was held in Montego Bay, Jamaica, during June 2–4, 2025. The 36 full and 2 short papers presented in this book were carefully reviewed and selected from 111 submissions. The papers presented in these volumes are organized into the following topical sections:- Part I: Emerging DSR Methods and Novel DSR Applications; Data-Driven Design Science; DSR Education; Healthcare Systems, Ageing and Wellbeing Part II: Responsible Artificial Intelligence Design; Cybersecurity, Privacy, and Ethics; Innovation and Entrepreneurship; Sustainable Development and Environmental Solutions