This Book Constitutes The Thoroughly Refereed Post-conference Proceedings Of The 4th International Conference On Intelligence Science And Big Data Engineering, Iscide 2013, Held In Beijing, China, In July/august 2013. The 111 Papers Presented Were Carefully Peer-reviewed And Selected From 390 Submissions. Topics Covered Include Information Theoretic And Bayesian Approaches; Probabilistic Graphical Models; Pattern Recognition And Computer Vision; Signal Processing And Image Processing; Machine Learning And Computational Intelligence; Neural Networks And Neuro-informatics; Statistical Inference And Uncertainty Reasoning; Bioinformatics And Computational Biology; And Speech Recognition And Natural Language Processing.