This book constitutes the proceedings of the Second International Conference on Artificial Intelligence: Towards Sustainable Intelligence, AI4S 2024, held in Alcala de Henares, Spain, during October 3-4, 2024. The 16 full papers and 2 short papers included in this book were carefully reviewed and selected from 59 submissions. They deal with trustworthy AI and related topics, focusing on software and its engineering; software development process management and methods, etc.