Author Description

3.4.3.1 Issues with the Adjusted Association -- 3.4.3.2 Issues with the Relative Effect -- 3.5 Should the Single-Trial Methods Be Used in Practice? -- II: Contemporary Surrogate Endpoint Evaluation Methods: Multiple-Trial Methods -- 4: Two Continuous Outcomes -- 4.1 Introduction -- 4.2 The Meta-Analytic Framework -- 4.2.1 Trial-Level Surrogacy -- 4.2.2 Individual-Level Surrogacy -- 4.3 Simplified Model-Fitting Strategies -- 4.3.1 Trial Dimension: Fixed- vs. Random-Effects Models -- 4.3.2 Model Dimension: Full vs. Reduced Models -- 4.3.3 Endpoint Dimension: Univariate vs. Bivariate Models