This book aims to revolutionize information research by introducing a receptive relation understanding of information, which systematically unveils its fundamental characteristics: created ex nihilo, emergence, reciprocity and shareability. Through a thorough exploration of organismic and sensory receptivity, the book establishes a mechanistic foundation for understanding the nature of information. It navigates the origins of biological information and leads readers into a new era of information studies. Offering a fresh perspective on the nature of information, it delves into its physical, digital, and ideational encodings, as well as the ideational system built upon them. The book sheds light on critical issues such as quantum manifestation of information and the fundamental laws governing the relationship between information and matter/energy. It also dispels common misconceptions about information and its role in the evolution of information civilization. The book provides valuable insights into understanding artificial general intelligence and the mysteries of consciousness and life. It will be of interest to researchers and students of information philosophy, information science, and artificial intelligence.