This book constitutes the proceedings of the 10th International Conference on Health Information Science, HIS 2021, which took place in Melbourne, Australia, in October 2021. The 16 full papers and 7 short papers presented in this volume were carefully reviewed and selected from 56 submissions. They are organized in topical sections named: COVID-19, EEG data processing, Medical Data Analysis, Medical Record Mining (I), Medical Data Mining (II), Medical Data Processing.