The aim of this Reprint is to attract scholars and managers interested in carbon peak and carbon neutrality. This Reprint includes all 13 articles in the Special Issue "Regional Sustainable Management Pathways to Carbon Neutrality", aiming to unlock the full potential of carbon neutrality pathways and helping the scholars share their insights, fundings, conclusions and future research prospects. All the articles focused on carbon emissions and carbon reduction, with a complete research framework including spatiotemporal variations, balance analysis, socioeconomic impacts, scenario analysis, and policy recommendations. We have made great efforts to seek the sustainable management pathways to carbon neutrality through evaluating the carbon balance statuses, analyzing the relationship between carbon emissions and the nature-social-economic system, and predicting the future trends of carbon emissions. All contents are conducive to the harmony between human and nature and global sustainable development.