Part of the What Do I Do Now? Pain Medicine series,<em> Painful Conditions of the Upper Limb</em> presents clinical scenarios related to painful syndromes affecting the neck, shoulder, arm, and hand. Upper limb pain can be complex to evaluate and manage given its multiple potential etiologies, complex anatomical structures, and pain referral patterns. This volume focuses on common presenting symptoms and expands from common diagnoses and syndromes to more complex conditions that require extensive diagnostic evaluation, comprehensive approaches, and complex management strategies. Clinical scenarios will also cover the multitude of cumulative trauma disorders and their resulting functional and vocational effects, with special attention to rehabilitative management and functional restoration. Throughout, chapters emphasize proper evaluation, discussing history and physical exam findings, differential diagnosis, appropriate ancillary testing, and management methods using specific restorative approaches, particularly non-opioid and mostly non-pharmacological options.