This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: - Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine - Lessons from Sicilian centenarians for anti-aging medicine - Molecular biomarkers and genetic aspects of aging - Future of peptides in clinical practice - Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection - Tissue-specific autoantibodies in preventive medicine - Chronic stress as a psycho-neuro-immunological dysfunction - Gut-associated immune system and its health implications - Regenerative medicine with platelet-rich-plasma - Alzheimer's disease: Preventive and anti-aging neurology - Autistic spectrum disorder and mitochondrial medicine - Integrative hormonal approach in anti-aging medicine - Preventive cardiology and phlebology - Aesthetic and anti-aging medicine - Preventive ophthalmology - Preventive oncology - Nutrition in healthy aging - Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new "standard of anti-aging medicine" and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.