This book gathers high-quality peer-reviewed research papers presented at the International Conference on Intelligent Computing and Networking (IC-ICN 2021), organized by the Computer Department, Thakur College of Engineering and Technology, in Mumbai, Maharashtra, India, on February 26-27, 2021. The book includes innovative and novel papers in the areas of intelligent computing, artificial intelligence, machine learning, deep learning, fuzzy logic, natural language processing, human-machine interaction, big data mining, data science and mining, applications of intelligent systems in health,care, finance, agriculture and manufacturing, high-performance computing, computer networking, sensor and wireless networks, Internet of Things (IoT), software-defined networks, cryptography, mobile computing, digital forensics, and blockchain technology..