The two-volume set, CCIS 2184-2185, constitutes the refereed proceedings of the First International Conference on Computation of Artificial Intelligence and Machine Learning, ICCAIML 2024, held in Jaipur, India, in January 18–19, 2024. The 60 papers included in these volumes were carefully reviewed and selected from 645 submissions. These papers focus on various subject areas within the field of Artificial Intelligence and Machine Learning, such as Neural Networks and Deep Learning, Natural Language Processing, Computer Vision, Reinforcement Learning, Data Mining and Big Data Analytics, AI in Healthcare and Biomedical Applications, Autonomous Systems and Robotics, AI Ethics and Fairness, AI in Finance and Eco-nomics.