This book constitutes the refereed proceedings of the 10th European Conference on Artificial Intelligence in Music, Sound, Art and Design, EvoMUSART 2021, held as part of Evo* 2021, as Virtual Event, in April 2021, co-located with the Evo* 2021 events, EvoCOP, EvoApplications, and EuroGP. The 24 revised full papers and 7 short papers presented in this book were carefully reviewed and selected from 66 submissions. They cover a wide range of topics and application areas, including generative approaches to music and visual art, deep learning, and architecture.