This volume LNCS-IFIP constitutes the refereed proceedings of the 7th IFIP TC 5, TC 12, WG 8.4, WG 8.9, WG 12.9 International Cross-Domain Conference, CD-MAKE 2023 in Benevento, Italy, during August 28 – September 1, 2023. The 18 full papers presented together were carefully reviewed and selected from 30 submissions. The conference focuses on integrative machine learning approach, considering the importance of data science and visualization for the algorithmic pipeline with a strong emphasis on privacy, data protection, safety and security.