This book constitutes the refereed proceedings of the 6th International Symposium on Cyber Security Cryptography and Machine Learning, CSCML 2022, held in Be'er Sheva, Israel, in June - July 2022. The 24 full and 11 short papers presented together with a keynote paper in this volume were carefully reviewed and selected from 53 submissions. They deal with the theory, design, analysis, implementation, or application of cyber security, cryptography and machine learning systems and networks, and conceptually innovative topics in these research areas.